Interaction of kanamycin A and kanamycin B with phospholipids.
نویسندگان
چکیده
منابع مشابه
Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus via metabolic engineering
Both kanamycin A and kanamycin B, antibiotic components produced by Streptomyces kanamyceticus, have medical value. Two different pathways for kanamycin biosynthesis have been reported by two research groups. In this study, to obtain an optimal kanamycin A-producing strain and a kanamycin B-high-yield strain, we first examined the native kanamycin biosynthetic pathway in vivo. Based on the prop...
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A kanamycin-producing strain, Streptomyces kanamyceticus ISP5500, is resistant to kanamycin. A kanamycin resistance determinant was cloned from S. kanamyceticus into Streptomyces lividans 1326, using the plasmid vector pIJ702. The resulting plasmid, pMCP5, could also transform Streptomyces lavendulae S985 and Streptomyces parvulus 2283 to kanamycin resistance. Transformants carrying pMCP5 were ...
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A strain of Proteus vulgaris isolated from the urinary tract of a patient with postoperative pyelonephritis and resistant to sulfonamide, streptomycin, tetracycline, and kanamycin (KM) was found to transfer only KM resistance by cell-to-cell conjugation. The genetic determinant controlling the transferable KM resistance was considered to be an R factor and was designated R (KM). Successive tran...
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A 22 year-old lady with multi-drug-resistant pulmonary tuberculosis was on Kanamycin, Cycloserine, Ethionamide, Pyrazinamide and Moxifloxacin since more than two months. She presented with muscle cramps and carpopedal spasm. Investigation revealed hypokalemia and metabolic alkalosis. She also had hypomagnesemia, hypochloremia and hypocalciuria. Serum urea and creatinine levels were normal. Pati...
متن کاملVentilatory effects of aerosolized kanamycin and polymyxin.
Inhalation of nebulized antibiotics is associated with respiratory distress in some patients but the effect on the airways has not been studied. Ventilatory function was studied immediately before and 20 minutes after inhalation in patients having chronic lung disease, who were being treated with inhaled antibiotics. Kanamycin was associated with minor changes in ventilatory function but polymy...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1987
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.40.862